Although the presently preferred embodiment of the invention contemplates the usage of the phosphodiesterase inhibitor sildenafil citrate as the popular lively for the strategies set forth herein in the therapy and/or prevention of EIPH, it is specifically contemplated that other phosphodiesterase inhibitors are within the scope of the invention. In particular, the invention relates to methods and gadgets for nebulization therapy in horses for the remedy and prevention of respiratory situations including Exercise-Induced Pulmonary Hemorrhage (EIPH) and associated pulmonary sequella in the horse. The foregoing and other objects, options and benefits of the present invention should turn into apparent to those of talent within the artwork in the following description when taken at the side of the accompanying drawings and by way of follow of the invention. Accordingly, there nonetheless exists a necessity within the artwork for such methods. In the embodiment proven, in FIG. 1, the device 10 and attachment means 20 are proven hooked up to the head 30 of the topic equine and mendacity beneath an ordinary equine halter 60. Thus, one of ability in the artwork can recognize that the machine 10 and attachment means 20 might be connected and used impartial of but in conjunction with halters, bridles or other equine head gear.
In the embodiment shown in FIG. 1, the attachment means 20 itself is a halter-kind or halter-like apparatus constructed of nylon or leather with adjustable straps for securing to the top 30 of the subject equine and is separate from halter 60. As set forth extra filly under, the attachment means 20 for the system 10 might be separate from halter 60 or built-in therein. The system 10 or equine nasal cannula might be designed to conform to or change into an integral part of harness and/or bridle or different halter-kind tools usually associated with the coaching and racing of equine athletes. Thus, the current invention offers an inhalation therapy regimen administered by means of, e.g., a non-invasive equine nasal cannula machine as additionally offered by the invention. In a presently preferred embodiment, the invention provides a way for the therapy or prevention of EIPH, whereby the composition for inhalant therapy is a mixture comprised of sildenafil citrate or its congeners (e.g., metabolites, isomers, salts or other lively derivatives of sildenafil citrate) using air as the supply vehicle to carry the inhalant into the equine mammal. In a single embodiment, the therapy regimen includes the introduction of a composition comprised of sildenafil citrate or congeners of sildenafil citrate with or with out potentiating brokers delivered to the topic equine via the attendant inhalation therapy system in a non-invasive method that is conducive to the care and comfort of the equine mammal beneath therapy.
The gadget 10 is held in place by attachment means 20 such that the distal ends 16, 18 of elongated delivery tubes 12, 14 (cannulas) are positioned adjacent the external openings 32, 34 of the subject equine's nasal cavity (adjoining the nares) in order to effectively deliver the composition chosen for inhalation at the appropriate site. In the presently most popular embodiment, the machine 10 of the invention (the equine nasal cannula) is comprised of a nylon attachment means 20 (similar to a halter) that is configured to adapt to the contours of the equine skull 30 in such a fashion as to successfully place and hold the distal ends 16, 18 of the elongated delivery tubes 12, 14 in a desired position for the administration of a therapeutic inhalant while minimizing the requirements for specialised animal restraint and/or restriction of motion. In one embodiment, padded extrusions (not shown) are offered at the distal ends 16, 18 (nasal finish) of the elongated tubes 12, 14 (cannulas) to forestall injury or irritation which will happen from rubbing the nostrils or the inner linings (mucosa) of the nostrils.
Thus, the dimensional and other traits proven in FIGS. FIG. 5 is a perspective view of one embodiment of the nebulization apparatus and air provide for supply of a desired therapeutic agent by way of the gadget of FIGS. FIG. 3 is a perspective view of one embodiment of the nasal cannula portion of the system of the invention. FIG. 7 is a coloration digital photograph showing a left frontal view of 1 embodiment of the device of the invention. It's an object of the invention to offer an inhalation therapy regimen and system for the therapy and/or prevention of EIPH comprising the inhalation of a therapeutic quantity of sildenafil citrate and/or the metabolites of sildenafil citrate alone or in combination with other compounds. Studied for its immune health advantages, N-Acetyl-L-Cysteine 98% wholesale suppliers defends in opposition to insults from international compounds. Generally talking, simple natural compounds formed by the substitute of a hydrogen atom of hydrogen sulfide by an aliphatic, aromatic or heterocyclic radical are known as "thiols," e.g. methanethiol; whereas, polyfunctional compounds so formed are sometimes described with the prefix "mercapto," such as mercaptoacetic acid.