Although the presently preferred embodiment of the invention contemplates the use of the phosphodiesterase inhibitor sildenafil citrate as the popular energetic for the strategies set forth herein in the therapy and/or prevention of EIPH, it is specifically contemplated that other phosphodiesterase inhibitors are inside the scope of the invention. Particularly, the invention pertains to strategies and units for nebulization therapy in horses for the therapy and prevention of respiratory situations including Exercise-Induced Pulmonary Hemorrhage (EIPH) and related pulmonary sequella in the horse. The foregoing and different objects, features and advantages of the current invention ought to become apparent to these of skill within the artwork in the next description when taken at the side of the accompanying drawings and through observe of the invention. Accordingly, there still exists a necessity in the artwork for such strategies. Within the embodiment proven, in FIG. 1, the gadget 10 and attachment means 20 are shown attached to the top 30 of the subject equine and lying beneath a normal equine halter 60. Thus, one in all skill in the art can admire that the system 10 and attachment means 20 could be connected and used impartial of however at the side of halters, bridles or other equine head gear.
In the embodiment proven in FIG. 1, the attachment means 20 itself is a halter-sort or halter-like apparatus constructed of nylon or leather with adjustable straps for securing to the top 30 of the topic equine and is separate from halter 60. As set forth more filly beneath, the attachment means 20 for the device 10 might be separate from halter 60 or integrated therein. The machine 10 or equine nasal cannula can be designed to conform to or grow to be an integral a part of harness and/or bridle or different halter-type gear normally related to the training and racing of equine athletes. Thus, the current invention offers an inhalation therapy regimen administered by means of, e.g., a non-invasive equine nasal cannula device as also provided by the invention. In a presently most popular embodiment, the invention supplies a way for the therapy or prevention of EIPH, wherein the composition for inhalant therapy is a mixture comprised of sildenafil citrate or its congeners (e.g., metabolites, isomers, salts or different active derivatives of sildenafil citrate) using air because the delivery automobile to hold the inhalant into the equine mammal. In one embodiment, the therapy regimen contains the introduction of a composition comprised of sildenafil citrate or congeners of sildenafil citrate with or without potentiating agents delivered to the subject equine via the attendant inhalation therapy system in a non-invasive manner that's conducive to the care and comfort of the equine mammal beneath therapy.
The device 10 is held in position by attachment means 20 such that the distal ends 16, 18 of elongated delivery tubes 12, 14 (cannulas) are placed adjoining the exterior openings 32, 34 of the topic equine's nasal cavity (adjoining the nares) so as to effectively deliver the composition selected for inhalation at the suitable site. Within the presently preferred embodiment, the gadget 10 of the invention (the equine nasal cannula) is comprised of a nylon attachment means 20 (similar to a halter) that is configured to adapt to the contours of the equine skull 30 in such a fashion as to effectively place and hold the distal ends 16, 18 of the elongated delivery tubes 12, 14 in a desired place for the administration of a therapeutic inhalant whereas minimizing the requirements for specialised animal restraint and/or restriction of motion. In one embodiment, padded extrusions (not proven) are provided at the distal ends 16, 18 (nasal finish) of the elongated tubes 12, 14 (cannulas) to forestall injury or irritation which will occur from rubbing the nostrils or the inner linings (mucosa) of the nostrils.
Thus, the dimensional and different traits shown in FIGS. FIG. 5 is a perspective view of one embodiment of the nebulization apparatus and air provide for supply of a desired therapeutic agent through the machine of FIGS. FIG. Three is a perspective view of 1 embodiment of the nasal cannula portion of the machine of the invention. FIG. 7 is a shade digital photograph showing a left frontal view of 1 embodiment of the device of the invention. It is an object of the invention to offer an inhalation therapy regimen and system for the treatment and/or prevention of EIPH comprising the inhalation of a therapeutic quantity of sildenafil citrate and/or the metabolites of sildenafil citrate alone or in combination with other compounds. Studied for its immune health benefits, N-Acetyl-L-Cysteine 98% custom sourcing defends in opposition to insults from international compounds. Generally talking, easy natural compounds formed by the alternative of a hydrogen atom of hydrogen sulfide by an aliphatic, aromatic or heterocyclic radical are known as "thiols," e.g. methanethiol; whereas, polyfunctional compounds so formed are sometimes described with the prefix "mercapto," akin to mercaptoacetic acid.